Some Viney Bushes contain Snake Dens. When these are approached, or attempted to be hacked with a Machete, Snakes will spawn and attack the offender. Additionally, the Snakes will leave the den at Dusk, roam around all night and go back to their den at dawn. Snake infested Viney Bushes will make hissing sounds and periodically shake, allowing them to be distinguished from normal Viney Bushes. Each Snake den contains up to 3 Snakes. If one or more of the Snakes are killed, a new one will spawn every 90 seconds to replace them.
- A Spider Den next to a Snake Den will result in nightly battles between the two. Monster Meat will be eaten if not picked up quickly, but Spider Glands, Silk and Snakeskin will be left on the ground. Wearing a Spiderhat while collecting will prevent spiders from attacking.
- If the bush is chopped down while the snakes are outside, the bush will look fully grown when the snakes return to it.
- If a Snake Den Viney Bush withers during Dry Season, the bush will look fully grown when the snakes spawn.